5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]pentanoic acid (2,3,4,5,6-pentafluorophenyl) ester
Fmoc-Arg(Pbf)-OPfp
CAS: 200132-16-7;7004-12-8
Molecular Formula: C40H39F5N4O7S
5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]pentanoic acid (2,3,4,5,6-pentafluorophenyl) ester - Names and Identifiers
5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]pentanoic acid (2,3,4,5,6-pentafluorophenyl) ester - Physico-chemical Properties
| Molecular Formula | C40H39F5N4O7S |
| Molar Mass | 814.82 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.616 |
5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]pentanoic acid (2,3,4,5,6-pentafluorophenyl) ester - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2935 90 90 |
5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]pentanoic acid (2,3,4,5,6-pentafluorophenyl) ester - Introduction
Fmoc-Arg(Pbf)-OPfp, or Fmoc-Arg(pbf)-OH, is a commonly used reagent for protecting amino acids. It is a white crystalline solid, soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol.
Fmoc-Arg(pbf)-OH is commonly used in peptide synthesis in solid phase synthesis as a protective reagent for amino acids. It can protect the amino group of arginine, so as to avoid the side reaction and degradation of arginine. In the synthesis, Fmoc-Arg(pbf)-OH can be linked to other amino acids by reaction and released by deprotection reaction.
The preparation method of Fmoc-Arg(pbf)-OH is relatively complicated. Generally, it can be obtained by the reaction of 2,2,4,6, 7-pentamethyldihydrobenzofuran (HMPA) and p-bromobenzenesulfonyl chloride(p-BSCl) to give 2,2,4,6, 7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride (HMPA-Cl). The HMPA-Cl is then reacted with N-alpha-Fmoc-L-arginine pentafluorophenyl ester to give Fmoc-Arg(pbf)-OH.
Regarding safety information, Fmoc-Arg(pbf)-OH is a chemical reagent and has certain risks. During use and handling, it is necessary to take appropriate safety measures, such as wearing personal protective equipment such as gloves and goggles, and avoid contact with skin and eyes. In addition, care should be taken to store in a cool and dry place, away from fire and flammable materials. Seek immediate medical help in case of accidental contact or inhalation.
Fmoc-Arg(pbf)-OH is commonly used in peptide synthesis in solid phase synthesis as a protective reagent for amino acids. It can protect the amino group of arginine, so as to avoid the side reaction and degradation of arginine. In the synthesis, Fmoc-Arg(pbf)-OH can be linked to other amino acids by reaction and released by deprotection reaction.
The preparation method of Fmoc-Arg(pbf)-OH is relatively complicated. Generally, it can be obtained by the reaction of 2,2,4,6, 7-pentamethyldihydrobenzofuran (HMPA) and p-bromobenzenesulfonyl chloride(p-BSCl) to give 2,2,4,6, 7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride (HMPA-Cl). The HMPA-Cl is then reacted with N-alpha-Fmoc-L-arginine pentafluorophenyl ester to give Fmoc-Arg(pbf)-OH.
Regarding safety information, Fmoc-Arg(pbf)-OH is a chemical reagent and has certain risks. During use and handling, it is necessary to take appropriate safety measures, such as wearing personal protective equipment such as gloves and goggles, and avoid contact with skin and eyes. In addition, care should be taken to store in a cool and dry place, away from fire and flammable materials. Seek immediate medical help in case of accidental contact or inhalation.
Last Update：2024-04-09 20:52:54
![5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]pentanoic acid (2,3,4,5,6-pentafluorophenyl) ester](http://res.chembk.com/assets/images/structure/200132-16-7.gif)
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